Nike Vaporfly: carbon fibre plate and ZoomX foam. The carbon plate is stiffer and more propulsive at race pace. ZoomX is extremely lightweight and highly responsive.
Saucony Endorphin Speed: nylon plate and PWRRUN PB foam. The nylon plate provides propulsion with more flexibility than carbon. PWRRUN PB is responsive and cushioned but not the same as ZoomX.
The Vaporfly's carbon plate and ZoomX combination is specifically designed to reduce the energy cost of running at race pace. At elite and sub-elite levels, this is measurable. At recreational pace, the difference narrows — but the Vaporfly is still a more propulsive ride at sustained effort.
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Source: specifications from saucony.com and nike.com.