The Kayano is one of the most structured options in mainstream running. It has a high stack, strong medial post, and significant reinforcement throughout the upper and midsole. For runners with significant overpronation, this level of support is appropriate.
The Guide is more moderate. Its medial post provides stability without the bulk of the Kayano. Runners with mild-to-moderate overpronation often find the Guide more comfortable because it does not overcorrect.
The Kayano is heavier and more structured. The Guide is lighter and more flexible. Runners who find structured stability shoes uncomfortable over longer distances often find the Guide easier to run in.
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Source: specifications from saucony.com and asics.com.